Canadian Health Information Management Association Practice Exam

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Study for the Canadian Health Information Management Association Exam. Utilize flashcards and multiple choice questions with explanations. Prepare effectively for your exam!

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Which cells are responsible for producing histamine in a type 1 hypersensitivity reaction?

Lymphocytes.
Macrophages.
Mast cells.
Neutrophils.

The correct answer is: Mast cells.

In a type 1 hypersensitivity reaction, mast cells play a crucial role in producing histamine. These specialized cells are a type of immune cell found in various tissues throughout the body, particularly in locations prone to allergens, such as the skin and mucosal surfaces. When an allergen interacts with specific IgE antibodies bound to mast cells, it triggers the degranulation process, leading to the release of histamine and other inflammatory mediators. Histamine is responsible for many of the characteristic symptoms associated with allergic reactions, such as itching, swelling, and vasodilation. This immediate response is a hallmark of type 1 hypersensitivity and underlines the crucial role of mast cells in the body's immune response to allergens. Understanding this mechanism is essential for recognizing the pathophysiology involved in allergic reactions and the therapeutic approaches used to manage them.